DBT-NIBMG created world’s first database of genomic variants of oral cancer
DBT-National Institute of Biomedical Genomics (NIBMG), Kalyani an Autonomous Institute has created a database of genomic variations in oral cancer; the first of its kind in the world.
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dbGENVOC is a browsable online database of GENomic Variants of Oral Cancer and is a free resource.
First release of dbGENVOC contains
- ~24 million somatic and germline variants derived from whole exome sequences of 100 Indian oral cancer patients and whole genome sequences of 5 oral cancer patients from India
- somatic variation data from 220 patient samples drawn from the USA and analyzed by TCGA-HNSCC project
- manually curated variation data of 118 patients from recently published peer-reviewed publications.
dbGENVOC is not just a catalogue of genomic variants, it has a built-in powerful search engine.
It also allows a reasonable extent of statistical and bioinformatic analysis to be carried out online, including identifying variants in associated altered pathways in oral cancer.