Q. Which one of the following amino acid residues will destabilize an \u03b1-helix when inserted in the middle of the helix?<\/p>\n\n\n\n
(A) Pro<\/strong><\/p>\n\n\n\n (B) Val<\/p>\n\n\n\n (C) Ile<\/p>\n\n\n\n (D) Leu<\/p>\n\n\n\n Ans: Pro<\/strong><\/p>\n\n\n\n Solution: <\/p>\n\n\n\n (A) Pro<\/p>\n\n\n\n Proline (Pro) is the amino acid residue that will destabilize an \u03b1-helix when inserted in the middle of the helix.<\/p>\n\n\n\n The \u03b1-helix is a common secondary structure in proteins, characterized by a right-handed helical coil stabilized by hydrogen bonds between the backbone amide hydrogen and carbonyl oxygen of the peptide bonds. In an \u03b1-helix, the backbone forms a repeating pattern with a rise of 1.5 \u00c5 per residue and a 3.6 amino acids per turn.<\/p>\n\n\n\n Proline is unique among the standard 20 amino acids because its side chain forms a covalent bond with the amino group of its own backbone, creating a rigid cyclic structure. This conformational constraint prevents Proline from easily fitting into the regular hydrogen bonding pattern of an \u03b1-helix. When Proline is inserted in the middle of an \u03b1-helix, it disrupts the regular hydrogen bonding, leading to a kink or distortion in the helix. This destabilizing effect makes Proline a helix breaker and is why it is rarely found in the middle of \u03b1-helices.<\/p>\n","protected":false},"excerpt":{"rendered":" Q. Which one of the following amino acid residues will destabilize an \u03b1-helix when inserted in the middle of the helix? (A) Pro (B) Val (C) Ile (D) Leu Ans: Pro Solution: (A) Pro Proline (Pro) is the amino acid residue that will destabilize an \u03b1-helix when inserted in the middle of the helix. The […]<\/p>\n","protected":false},"author":419,"featured_media":153321,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[5141],"tags":[5140],"class_list":["post-153320","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-gate","tag-gate-questions"],"_links":{"self":[{"href":"https:\/\/www.gkseries.com\/blog\/wp-json\/wp\/v2\/posts\/153320","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.gkseries.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.gkseries.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.gkseries.com\/blog\/wp-json\/wp\/v2\/users\/419"}],"replies":[{"embeddable":true,"href":"https:\/\/www.gkseries.com\/blog\/wp-json\/wp\/v2\/comments?post=153320"}],"version-history":[{"count":1,"href":"https:\/\/www.gkseries.com\/blog\/wp-json\/wp\/v2\/posts\/153320\/revisions"}],"predecessor-version":[{"id":153322,"href":"https:\/\/www.gkseries.com\/blog\/wp-json\/wp\/v2\/posts\/153320\/revisions\/153322"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.gkseries.com\/blog\/wp-json\/wp\/v2\/media\/153321"}],"wp:attachment":[{"href":"https:\/\/www.gkseries.com\/blog\/wp-json\/wp\/v2\/media?parent=153320"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.gkseries.com\/blog\/wp-json\/wp\/v2\/categories?post=153320"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.gkseries.com\/blog\/wp-json\/wp\/v2\/tags?post=153320"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}