{"id":25588,"date":"2020-07-25T08:02:10","date_gmt":"2020-07-25T08:02:10","guid":{"rendered":"https:\/\/www.gkseries.com\/blog\/?p=25588"},"modified":"2020-07-25T08:02:10","modified_gmt":"2020-07-25T08:02:10","slug":"mrna-based-vaccine-manufacturing-platform-in-india","status":"publish","type":"post","link":"https:\/\/www.gkseries.com\/blog\/mrna-based-vaccine-manufacturing-platform-in-india\/","title":{"rendered":"mRNA based vaccine manufacturing platform in India"},"content":{"rendered":"\n<p>DBT-BIRAC has facilitated the establishment of \u2018first-of-its-kind\u2019 mRNA-based vaccine manufacturing platform in India. DBT has provided seed funding for the development of Gennova\u2019s novel self-amplifying mRNA-based vaccine candidate for COVID19.<\/p>\n\n\n\n<p><a href=\"https:\/\/www.gkseries.com\/blog\/current-affairs-quiz-2019-daily-gk\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Daily Current Affairs Quiz 2020<\/strong><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Key-Points<\/strong><\/h2>\n\n\n\n<p>In collaboration with HDT Biotech Corporation, Seattle, USA, Gennova has developed an mRNA vaccine candidate (HGCO19), with demonstrated safety, immunogenicity, neutralization antibody activity in the rodent and non-human primate models.<\/p>\n\n\n\n<p>The company is working aggressively to ensure first human injection by the end of the year, subject to Indian regulatory approvals.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>About HGCO19<\/strong><\/h3>\n\n\n\n<p>The novel mRNA vaccine candidate, HGCO19, has all the necessary arsenal to guide the host cells to make the antigen -spike protein of the virus, reported to interact with host cells receptor, and supported by \u2018lipid inorganic nanoparticle (LION)\u2019 as a delivery vehicle.<\/p>\n\n\n\n<p>The neutralizing antibody response of the vaccine in mice and non-human primates was comparable with the sera from the convalescent patients of COVID-19, above the US-FDA recommended titre of 1:160 for neutralizing antibodies.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>About BIRAC<\/strong><\/h3>\n\n\n\n<p>Biotechnology Industry Research Assistance Council (BIRAC) is a not-for-profit Section 8, Schedule B, Public Sector Enterprise, set up by Department of Biotechnology (DBT), Government of India as an Interface Agency to strengthen and empower the emerging Biotech enterprise to undertake strategic research and innovation, addressing nationally relevant product development needs.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>About Gennova<\/strong><\/h3>\n\n\n\n<p>Gennova Biopharmaceuticals Ltd., headquartered in Pune, India, is a biotechnology company dedicated to the research, development, production, and commercialization of biotherapeutics to address life-threatening diseases across various indications.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>DBT-BIRAC has facilitated the establishment of \u2018first-of-its-kind\u2019 mRNA-based vaccine manufacturing platform in India. DBT has provided seed funding for the development of Gennova\u2019s novel self-amplifying mRNA-based vaccine candidate for COVID19. Daily Current Affairs Quiz 2020 Key-Points In collaboration with HDT Biotech Corporation, Seattle, USA, Gennova has developed an mRNA vaccine candidate (HGCO19), with demonstrated safety, [&hellip;]<\/p>\n","protected":false},"author":404,"featured_media":25589,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1175],"tags":[1010],"class_list":["post-25588","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-current-affairs-july-2020","tag-covid-19"],"_links":{"self":[{"href":"https:\/\/www.gkseries.com\/blog\/wp-json\/wp\/v2\/posts\/25588","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.gkseries.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.gkseries.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.gkseries.com\/blog\/wp-json\/wp\/v2\/users\/404"}],"replies":[{"embeddable":true,"href":"https:\/\/www.gkseries.com\/blog\/wp-json\/wp\/v2\/comments?post=25588"}],"version-history":[{"count":1,"href":"https:\/\/www.gkseries.com\/blog\/wp-json\/wp\/v2\/posts\/25588\/revisions"}],"predecessor-version":[{"id":25590,"href":"https:\/\/www.gkseries.com\/blog\/wp-json\/wp\/v2\/posts\/25588\/revisions\/25590"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.gkseries.com\/blog\/wp-json\/wp\/v2\/media\/25589"}],"wp:attachment":[{"href":"https:\/\/www.gkseries.com\/blog\/wp-json\/wp\/v2\/media?parent=25588"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.gkseries.com\/blog\/wp-json\/wp\/v2\/categories?post=25588"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.gkseries.com\/blog\/wp-json\/wp\/v2\/tags?post=25588"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}