{"id":29994,"date":"2020-04-30T08:14:00","date_gmt":"2020-04-30T08:14:00","guid":{"rendered":"https:\/\/www.gkseries.com\/blog\/?p=29994"},"modified":"2020-10-09T08:18:28","modified_gmt":"2020-10-09T08:18:28","slug":"jncasr-scientists-developed-a-natural-product-based-alzheimer-inhibitor","status":"publish","type":"post","link":"https:\/\/www.gkseries.com\/blog\/jncasr-scientists-developed-a-natural-product-based-alzheimer-inhibitor\/","title":{"rendered":"JNCASR scientists developed a natural product based Alzheimer inhibitor"},"content":{"rendered":"\n<p>JNCASR scientists have developed a natural product based Alzheimer inhibitor. Scientists from Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) have modified the structure of Berberine, a natural and cheap product similar to curcumin, available commercially, into Ber-D to use as a Alzheimer\u2019s inhibitor.<\/p>\n\n\n\n<p><a href=\"https:\/\/www.gkseries.com\/blog\/current-affairs-quiz-2019-daily-gk\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Daily Current Affairs Quiz 2020<\/strong><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Key-Points<\/h2>\n\n\n\n<p>The scientist selected isoquinoline natural product berberine found in India and China and used in traditional medicine and other applications.<\/p>\n\n\n\n<p>Because of berberine&#8217;s poor solubility and toxicity to cells, it was modified into Ber-D.<\/p>\n\n\n\n<p>Ber-D is soluble (aqueous), antioxidant.<\/p>\n\n\n\n<p>It is a multifunctional inhibitor of multifaceted amyloid toxicity of Alzheimer&#8217;s disease.<\/p>\n\n\n\n<p>Ber-D prevents the generation of reactive oxygen species (ROS) and rescues biomacromolecules from oxidative damage.<\/p>\n\n\n\n<p>Ber-D inhibits aggregations of metal-dependent and independent Amyloid beta (A\u03b2). These are the peptides of amino acids crucially involved in Alzheimer&#8217;s disease as the main component of the amyloid plaques found in the brains of people with Alzheimer&#8217;s disease.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>JNCASR scientists have developed a natural product based Alzheimer inhibitor. Scientists from Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) have modified the structure of Berberine, a natural and cheap product similar to curcumin, available commercially, into Ber-D to use as a Alzheimer\u2019s inhibitor. Daily Current Affairs Quiz 2020 Key-Points The scientist selected isoquinoline natural [&hellip;]<\/p>\n","protected":false},"author":404,"featured_media":29995,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1012],"tags":[68],"class_list":["post-29994","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-current-affairs-april-2020","tag-science-technology-current-affairs"],"_links":{"self":[{"href":"https:\/\/www.gkseries.com\/blog\/wp-json\/wp\/v2\/posts\/29994","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.gkseries.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.gkseries.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.gkseries.com\/blog\/wp-json\/wp\/v2\/users\/404"}],"replies":[{"embeddable":true,"href":"https:\/\/www.gkseries.com\/blog\/wp-json\/wp\/v2\/comments?post=29994"}],"version-history":[{"count":1,"href":"https:\/\/www.gkseries.com\/blog\/wp-json\/wp\/v2\/posts\/29994\/revisions"}],"predecessor-version":[{"id":29996,"href":"https:\/\/www.gkseries.com\/blog\/wp-json\/wp\/v2\/posts\/29994\/revisions\/29996"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.gkseries.com\/blog\/wp-json\/wp\/v2\/media\/29995"}],"wp:attachment":[{"href":"https:\/\/www.gkseries.com\/blog\/wp-json\/wp\/v2\/media?parent=29994"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.gkseries.com\/blog\/wp-json\/wp\/v2\/categories?post=29994"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.gkseries.com\/blog\/wp-json\/wp\/v2\/tags?post=29994"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}