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Free download in PDF Mutation Multiple Choice Questions and Answers for competitive exams. These short objective type questions with answers are very important for Board exams as well as competitive exams like NEET, AIIMS, JIPMER etc. These short solved questions or quizzes are provided by Gkseries.
(1)
Point mutation involves
[A]
deletion
[B]
insertion
[C]
duplication
[D]
change in single base pair
Answer: change in single base pair
(2)
Transition type of gene mutation is caused when
[A]
GC is replaced by TA
[B]
CG is replaced by GC
[C]
AT is replaced by CG
[D]
AT is replaced by GC
Answer: AT is replaced by GC
(3)
Gene mutation occurs at the time of
[A]
DNA repair
[B]
DNA replication
[C]
Cell division
[D]
RNA transcription
(4)
X rays causes mutation by
[A]
deletion
[B]
transition
[C]
transversion
[D]
base substitution
(5)
Which of the following have been developed by mutation?
[A]
Knol knol variety of castor
[B]
Aruna variety of barley
[C]
Erectiferum variety of cabbage
[D]
Reimei variety of Rice
Answer: Reimei variety of Rice
(6)
Which of the following is not ionising radiations are
[A]
X rays
[B]
UV rays
[C]
cosmic rays
[D]
alpha rays
(7)
In this study, the sole factor associated with poor recurrence-free survival in multivariate analysis is
[A]
Site of disease
[B]
Extent of resection
[C]
Duration of adjuvant therapy
[D]
Nuclear pleomorphism
Answer: Nuclear pleomorphism
(8)
Which of the following are driver mutations?
[A]
c-kit and DOG-1
[B]
PDGFR-α and DOG-1
[C]
c-kit and PDGFR-α
[D]
All of the above
Answer: c-kit and PDGFR-α
(9)
Choose the false statement pertaining to GIST
[A]
Wild-type GIST is c-kit and PDGFR-α negative
[B]
GISTs are always of gastrointestinal origin
[C]
Wild-type GIST can be DOG-1 positive
[D]
Wild-type GIST can be c-kit driven
Answer: GISTs are always of gastrointestinal origin
(10)
The most important prognostic factors in GIST are all, except
[A]
Tumor size
[B]
Site
[C]
Mitotic index
[D]
Lymph node involvement
Answer: Lymph node involvement
(11)
Regarding surgery in GIST, true statement is
[A]
Small tumors can be managed with maximal debulking
[B]
Retroperitoneal GISTs are easier to resect
[C]
Wide local excision is the standard of care
[D]
R+ resection is acceptable to save adjacent organs
Answer: Wide local excision is the standard of care
(12)
DOG-1 is a robust biomarker, it is
[A]
A diagnostic IHC marker of GIST
[B]
An activating mutation in the tyrosine kinase pathway
[C]
The most sensitive marker of GIST
[D]
May be positive in other soft tissue sarcomas
Answer: A diagnostic IHC marker of GIST
(13)
Adjuvant therapy in an R0 resected gastric GIST of 5 cm would be
[A]
Cytotoxic chemotherapy
[B]
None
[C]
Local radiation therapy
[D]
Tyrosine kinase inhibitor
Answer: Tyrosine kinase inhibitor
(14)
The characteristics of PDGFR-α in GIST are all, except
[A]
Is constitutively inactivated
[B]
can be expressed in other soft tissue tumors
[C]
can be detected by IHC
[D]
can be positive along with DOG-1
Answer: Is constitutively inactivated
(15)
Common sites of GIST in descending order as per incidence are
[A]
Ileum–duodenum–rectum–stomach
[B]
Stomach–ileum–duodenum–rectum
[C]
Rectum–ileum–duodenum–stomach
[D]
Duodenum– stomach–ileum–rectum
Answer: Stomach–ileum–duodenum–rectum
(16)
Which of the following mutations in GIST are mutually exclusive?
[A]
c-kit and PDGFR-α
[B]
c-kit and DOG-1
[C]
DOG-1 and PDGFR-α
[D]
None of the above
Answer: c-kit and PDGFR-α
(17)
What are the eukaryotic components of Mut S and Mut L of E. coli?
[A]
MSH, MLH
[B]
MHS, MHL
[C]
MLS, PMS
[D]
PMS, MHL
(18)
If the Mut H cuts the DNA at the 5’ side of the mismatch then which nuclease is activated?
[A]
Exonuclease VII
[B]
Exonuclease VIII
[C]
Exonuclease I
[D]
Exonuclease IX
(19)
By which enzyme does E. coli tags its parental DNA strand?
[A]
Methylase
[B]
Polymerase
[C]
Phosphorylase
[D]
Acetylase
(20)
The nicking of DNA is followed by the adherence of a helicase known as __________
[A]
Uvr D
[B]
Uvr A
[C]
Uvr B
[D]
Uvr C
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