Mutation MCQs | Mutation Multiple Choice Questions and Answers

Questions
1 Point mutation involves
A deletion
B insertion
C duplication
D change in single base pair

Answer: change in single base pair
2 Transition type of gene mutation is caused when
A GC is replaced by TA
B CG is replaced by GC
C AT is replaced by CG
D AT is replaced by GC

Answer: AT is replaced by GC
3 Gene mutation occurs at the time of
A DNA repair
B DNA replication
C Cell division
D RNA transcription

Answer: DNA replication
4 X rays causes mutation by
A deletion
B transition
C transversion
D base substitution

Answer: deletion
5 Which of the following have been developed by mutation?
A Knol knol variety of castor
B Aruna variety of barley
C Erectiferum variety of cabbage
D Reimei variety of Rice

Answer: Reimei variety of Rice
6 Which of the following is not ionising radiations are
A X rays
B UV rays
C cosmic rays
D alpha rays

Answer: UV rays
7 In this study, the sole factor associated with poor recurrence-free survival in multivariate analysis is
A Site of disease
B Extent of resection
C Duration of adjuvant therapy
D Nuclear pleomorphism

Answer: Nuclear pleomorphism
8 Which of the following are driver mutations?
A c-kit and DOG-1
B PDGFR-α and DOG-1
C c-kit and PDGFR-α
D All of the above

Answer: c-kit and PDGFR-α
9 Choose the false statement pertaining to GIST
A Wild-type GIST is c-kit and PDGFR-α negative
B GISTs are always of gastrointestinal origin
C Wild-type GIST can be DOG-1 positive
D Wild-type GIST can be c-kit driven

Answer: GISTs are always of gastrointestinal origin
10 The most important prognostic factors in GIST are all, except
A Tumor size
B Site
C Mitotic index
D Lymph node involvement

Answer: Lymph node involvement
11 Regarding surgery in GIST, true statement is
A Small tumors can be managed with maximal debulking
B Retroperitoneal GISTs are easier to resect
C Wide local excision is the standard of care
D R+ resection is acceptable to save adjacent organs

Answer: Wide local excision is the standard of care
12 DOG-1 is a robust biomarker, it is
A A diagnostic IHC marker of GIST
B An activating mutation in the tyrosine kinase pathway
C The most sensitive marker of GIST
D May be positive in other soft tissue sarcomas

Answer: A diagnostic IHC marker of GIST
13 Adjuvant therapy in an R0 resected gastric GIST of 5 cm would be
A Cytotoxic chemotherapy
B None
C Local radiation therapy
D Tyrosine kinase inhibitor

Answer: Tyrosine kinase inhibitor
14 The characteristics of PDGFR-α in GIST are all, except
A Is constitutively inactivated
B can be expressed in other soft tissue tumors
C can be detected by IHC
D can be positive along with DOG-1

Answer: Is constitutively inactivated
15 Common sites of GIST in descending order as per incidence are
A Ileum–duodenum–rectum–stomach
B Stomach–ileum–duodenum–rectum
C Rectum–ileum–duodenum–stomach
D Duodenum– stomach–ileum–rectum

Answer: Stomach–ileum–duodenum–rectum
16 Which of the following mutations in GIST are mutually exclusive?
A c-kit and PDGFR-α
B c-kit and DOG-1
C DOG-1 and PDGFR-α
D None of the above

Answer: c-kit and PDGFR-α
17 What are the eukaryotic components of Mut S and Mut L of E. coli?
A MSH, MLH
B MHS, MHL
C MLS, PMS
D PMS, MHL

Answer: MSH, MLH
18 If the Mut H cuts the DNA at the 5’ side of the mismatch then which nuclease is activated?
A Exonuclease VII
B Exonuclease VIII
C Exonuclease I
D Exonuclease IX

Answer: Exonuclease VII
19 By which enzyme does E. coli tags its parental DNA strand?
A Methylase
B Polymerase
C Phosphorylase
D Acetylase

Answer: Methylase
20 The nicking of DNA is followed by the adherence of a helicase known as __________
A Uvr D
B Uvr A
C Uvr B
D Uvr C

Answer: Uvr D
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