Organic Chemistry Multiple Choice Questions and Answers

(1) At which position of pyridine nucleophilic substitution reaction is most preferred?

[A] First and third

[B] Second

[C] Third

[D] Second and Forth

Answer: Second and Forth

(2) Pyridine undergoes nucleophilic substitution with NaNH2 at 100℃ to give which of the following?

[A] 3-aminopyridine

[B] 2-aminopyridine

[C] 3,5-diaminopyridine

[D] 2,5-diaminopyridine

Answer: 2-aminopyridine

(3) Pyridine undergoes nucleophilic substitution with excess of NaNH2 at 100℃ to give which of the following?

[A] 3-aminopyridine

[B] 2,6-diaminopyridine

[C] 3,5-diaminopyridine

[D] 2,5-diaminopyridine

Answer: 2,6-diaminopyridine

(4) What will be the product of the following reaction?

[A] 3-aminopyridine

[B] 2-aminopyridine

[C] 3,5-diaminopyridine

[D] 2,5-diaminopyridine

Answer: 2-aminopyridine

(5) What will be the product of the following reaction?

[A] 3-chloropyridine

[B] 2-dichloropyridine

[C] 3,5-dichloropyridine

[D] 2,5-dichloropyridine

Answer: 2-dichloropyridine

(6) Nucleophilic substitution reaction of pyridine is most effective in which of the conditions?

[A] In slightly acidic conditions

[B] In slightly basic conditions

[C] In neutral medium

[D] No specific condition requirements

Answer: No specific condition requirements

(7) What is the name of the following reaction?

[A] Chichibabin reaction

[B] Dealkylation of pyridine

[C] Hantzsch pyridine synthesis

[D] Bonnemann cyclisation

Answer: Chichibabin reaction

(8) Electron-withdrawing groups inhibit the Chichibabin reaction. Which of the following statement is not true about this fact?

[A] they increase the basicity of the ring nitrogen

[B] these electron-withdrawing groups can also form complexes with sodium amide

[C] for single electron transfer pathway, altering the distribution of spin density of the intermediate radical anion

[D] they slow down the sorption on sodium amide

Answer: they increase the basicity of the ring nitrogen

Organic Chemistry Questions and Answers – Nucleophilic Substitution in Pyridine | Organic Chemistry Multiple Choice Questions and Answers

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