Antigen and Antibody Objective Type Questions & Answers

Questions

21 Name the class of immunoglobulin which takes part in hypersensitivity reaction?

A IgG

B IgE

C IgA

D IgM

View Answer

Answer: IgE

22 Fluorescent treponemal antibody test is an example of

A indirect immunofluorescence

B direct immunofluorescence

C both (a) and (b)

D none of these

View Answer

Answer: indirect immunofluorescence

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23 Counter-immunoelectrophoresis is used for the detection of

A Meningococcal antigen

B Hepatitis B surface antigen

C Alpha-fetoprotein

D All of these

View Answer

Answer: All of these

Antigen and Antibody – Multiple Choice Questions with Answers | EBook

24 Commercially available ELISA kits are used for the detection of

A rotavirus

B hepatitis B surface antigen

C anti-HIV antibodies

D all of these

View Answer

Answer: all of these

25 Precipitation reaction is relatively less sensitive for the detection of

A antigens

B antigen-antibody complexes

C antibodies

D complement

View Answer

Answer: antibodies

26 All of the following are true of antigen EXCEPT which one of the following?

A They contain epitopes

B They will react with antibodies

C They contain antigenic determinants

D They contain paratopes

View Answer

Answer: They contain paratopes

27 All of the following are true about antibodies, EXCEPT which one?

A They fix complement

B They occur on the surface of B-lymphocyte

C They predominate the primary immune response to antigen

D They are molecule with a single, defined amino acid sequence

View Answer

Answer: They are molecule with a single, defined amino acid sequence

28 Which of the following statements best characterizes an antibody?

A An antibody contains high molecular weight RNA as its basic structure

B An antibody is composed of protein and cannot be distinguished from the albumin fraction of the serum proteins

C An antibody is composed of four identical protein subunits which may be caused to dissociate by treatment with urea

D An antibody contains protein as its major chemical component and its synthesis may be elicited by the administration of a foreign protein or polysaccharide

View Answer

Answer: An antibody contains protein as its major chemical component and its synthesis may be elicited by the administration of a foreign protein or polysaccharide

29 Individuals unable to make the J protein found in certain immunoglobulins would be expected to have frequent infections of the

A brain

B blood

C liver

D intestinal tract

View Answer

Answer: All of these

30 All of the following are true with respect to IgM antibodies EXCEPT which one

A they fix complement

B they occur on the surface of lymphocytes

C they predominate in the primary response to antigen

D they mediate allergic reaction

View Answer

Answer: they mediate allergic reaction

31 One principal function of complement is to

A inactivate perforins

B mediate the release of histamine

C Bind antibodies attached to cell surfaces and to lyse these cells

D phagocytize antigens

View Answer

Answer: Bind antibodies attached to cell surfaces and to lyse these cells

32 The major role of the complement system is to work in conjunction with

A antibodies to lyse cells via the C8 and C9 components

B the major histocompatibility complex for cell recognition

C antibodies to opsonize cells

D the T-cell receptor for production of lymphokines

View Answer

Answer: antibodies to lyse cells via the C8 and C9 components

33 T-cell antigen receptors are distinguished from antibodies by which of the following

A T-Cell receptors are glycosylated

B T-cell receptors must interact with antigen uniquely presented by other cells but not with free antigen

C T-Cell receptors bind various cytokines

D T-Cell receptors bind complement to lyse cells

View Answer

Answer: T-cell receptors must interact with antigen uniquely presented by other cells but not with free antigen

34 T-cell receptors or antibodies react with antigens

A because both are made by lymphocytes

B because of complementary of molecular fit of both with antigen

C because both 'have light chain and heavy chain polypeptides

D cause histamine release

View Answer

Answer: because of complementary of molecular fit of both with antigen

35 The major immunoglobulin family to which a particular immunoglobulin belongs can be determined by sequential analysis of the 110 amino acids beginning from the

A Amino terminus of the light chain

B Carboxy terminus of the light chain

C Amino terminus of the heavy chain

D Carboxy terminus of the heavy chain

View Answer

Answer: Carboxy terminus of the heavy chain

36 The immunoglobulin Joining chain (J-chain) is

A only produced by T-Cells

B only produced by neutrophils

C associated with only multimeric forms of lgM and IgA

D associated with IgE for histamine release

View Answer

Answer: associated with only multimeric forms of lgM and IgA

37 All of the following are true EXCEPT

A An epitope is a small portion of a macromolecule

B the variable region domains contain the antigen recognition site

C an antigenic determinant is a paratope

D The class of an immunoglobulin is determined by its heavy chain

View Answer

Answer: an antigenic determinant is a paratope

38 When a B-cell undergoes immunoglobulin class switching

A the variable region of the light chain changes, but its constant region remains the sam

B the variable region of the light chain remains the same, but its constant region changes

C the variable region of the heavy chain remains the same but its constant region changes

D both the variable and constant regions change

View Answer

Answer: the variable region of the heavy chain remains the same but its constant region changes

39 The class of an immunoglobulin

A is determined by Class I and Class II major histocompatibility complex proteins

B is determined by the carbohydrate attached to the light chain is

C determined by the antigen

D is determined by the heavy chain type

View Answer

Answer: is determined by the heavy chain type

40 The immunoglobulin class which is the least abundant in the normal adult is

A IgG

B IgA

C IgM

D IgE

View Answer

Answer: IgA

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