Molecular Basis of Inheritance MCQs | Molecular Basis of Inheritance Objective Type Questions with Answers

Questions
1 Type I topoisomerase can never decatenate catenated circular DNA?
A True
B False

Answer:False
2 The promotion of DNA breaking and rejoining by topoisomerase requires______________
A High – energy cofactor
B Ligase
C DNase I
D No external enzyme required

Answer: No external enzyme required
3 Attack of the topoisomerase gives rise to ____________
A Hydroxy – valine linkage
B Phospho – tyrosine linkage
C Hydroxy – cystine linkage
D Phospho – proline linkage

Answer:Phospho – tyrosine linkage
4 To reseal the DNA backbone where does topoisomerase gets the energy from?
A ATP hydrolysis
B High energy cofactor
C Phosphodiester cleavage
D Phosphotyrosine cleavage

Answer:Phosphodiester cleavage
5 Which of the following does not occur during cell division in prokaryotes?
A Multiple decatenations
B DNA cleavage
C DNA rejoining
D Strand passage

Answer: Multiple decatenations
6 The active site of the topoisomerase contains a tyrosine residue.
A True
B False

Answer:True
7 Nucleosome was first described in 1974 by ___________
A William Asbury
B Rosalind Franklin
C Roger Kornberg
D John Crick

Answer:Roger Kornberg
8 The extent of chromosome coiling in non – dividing cells is _________
A Supercoiled
B Euchromatin
C Condensed
D Heterochromatin

Answer:Euchromatin
9 The whole length of DNA is transcriptionally active.
A True
B False

Answer:False
10 Why are chromosomes condensed?
A To facilitate accommodation
B Always condensed
C To facilitate cell division
D To facilitate distribution in daughter cells

Answer:To facilitate distribution in daughter cells
11 At which phase do transcription ceases?
A Interphase
B Prophase
C S phase
D G phase

Answer:Prophase
12 The part that plays a critical role in even distribution of parental DNA during division is ___________
A Telomere
B Centromere
C Spindle fibre
D Centrioles

Answer: Centromere
13 With respect to centromere which of the following is wrong?
A Constricted chromosomal region
B Holds the sister chromatids together
C Attaches to spindle fibres
D Facilitates even distribution

Answer: Facilitates even distribution
14 The protein that binds to the spindle fibres are known as centromeric proteins.
A True
B False

Answer: False
15 Centromeric DNA was initially defined in ___________
A Bacteria
B Fungi
C Yeast
D Human

Answer:Yeast
16 How many satellite sequence elements are present in yeast centromere?
A 2
B 3
C 4
D 5

Answer:3
17 The centromere is A/T rich region.
A True
B False

Answer:True
18 Which alternate form of histone is seen in centromeric histones of humans?
A H2A.z
B SMC protein
C H1
D CENP-A

Answer:CENP-A
19 Telomere is not related to __________
A Maintenance
B Chromosome degradation
C Division
D Replication

Answer: Division
20 Which of the following nucleotides is rich I telomere of an organism?
A A, T
B T, G
C G, C
D C, A

Answer: G, C
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