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Free download in PDF Molecular Basis of Inheritance Very Short Questions and Answers for competitive exams. These short objective type questions with answers are very important for Board exams as well as competitive exams like NEET, AIIMS, JIPMER etc. These short solved questions or quizzes are provided by Gkseries./p>
(1)
With respect to the palm domain of the DNA polymerase which of the following is not its property?
[A]
Contains primary elements of the catalytic site
[B]
Binds to 2 divalent ions
[C]
Composed of α helix
[D]
Brings about the environmental changes around 3’-OH of dNTP
Answer: Composed of α helix
(2)
The two divalent metal ions of the active sites of DNA polymerase are major catalytic elements that bring about changes required for the joining of the dNTPs.
(3)
Mismatched DNA does not affect the rate of activity of DNA polymerase.
(4)
Which is the rate limiting step of DNA replication?
[A]
Formation of the RNA primer
[B]
Binding of primer to the DNA template
[C]
Binding of DNA polymerase to the primer:template junction
[D]
Binding of the first dNTP to the primer
Answer: Binding of DNA polymerase to the primer:template junction
(5)
Which of the following is not true about nucleotides?
[A]
Monomeric units
[B]
Ubiquitous substances
[C]
Energy rich molecules
[D]
Non enzymatic molecules
Answer: Non enzymatic molecules
(6)
The nitrogenous base is covalently linked to the _________ carbon of the pentose sugar.
[A]
C1
[B]
C2
[C]
C3
[D]
C4
(7)
In which carbon do the deoxyribonucleotides lack an –OH molecule?
[A]
C1
[B]
C2
[C]
C3
[D]
C4
(8)
Which of the following is not a part of a nucleotide?
[A]
Ester linkage
[B]
Phosphate group
[C]
Base
[D]
Hydrogen bond
(9)
Which of the following is not a part of a nucleoside?
[A]
Deoxyribose sugar
[B]
Glycosidic linkage
[C]
Phosphate
[D]
Base
(10)
The linkage between the sugar and the base is a covalent linkage.
(11)
Which of the following is not a nucleotide?
[A]
AMP
[B]
TMP
[C]
GMP
[D]
CMP
(12)
Purines and pyrimidines form glycosidic linkage with the purines and pyrimidines at the N6 position.
(13)
With respect to DNA polymerase holoenzyme pick the odd one out.
[A]
2 copies of DNA polymerase III
[B]
5 protein γ complex
[C]
Presence of ATP
[D]
Presence of DNA
(14)
A complete DNA polymerase III holoenzyme contains ____________ subunits.
(15)
How many polymerases are present in a replication fork?
(16)
With respect to eukaryotic replication which of the following enzyme is not correctly paired with its function?
[A]
Primase – initiation of new strand synthesis
[B]
RF-C – recruitment, maintenance and coordination of DNA polymerases
[C]
DNA polymerase ε – elongation of DNA strand
[D]
τ protein – binds to DNA polymerase
Answer: RF-C – recruitment, maintenance and coordination of DNA polymerases
(17)
The formation of the phosphodiester bond is an example of _________ reaction.
[A]
SN1
[B]
SN2
[C]
E1
[D]
E2
(18)
DNA synthesis is known as a coupled process.
(19)
DNA helicase travels along _________
[A]
Leading strand template in 3’→5’ direction
[B]
Leading strand template in 5’→3’ direction
[C]
Lagging strand template in 3’→5’ direction
[D]
Lagging strand template in 5’→3’ direction
Answer: Lagging strand template in 5’→3’ direction
(20)
DNA polymerase III holoenzyme does not need to interact with the helicase during replication.
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