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Free download in PDF Objective Type Questions with Answers on Molecular Basis of Inheritance for competitive exams. These short objective type questions with answers are very important for Board exams as well as competitive exams like NEET, AIIMS, JIPMER etc. These short solved questions or quizzes are provided by Gkseries./p>
(1)
Amino acids prior to their incorporation into polypeptide must be attached to a special adaptor molecule. Who proved this and when?
[A]
Francis H. Crick in 1955
[B]
Paul C. Zamecnic and Maholon B. Hoagland in 1957
[C]
James Watson and Francis H. Crick in 1953
[D]
Linus Pauling in 1950
Answer: Paul C. Zamecnic and Maholon B. Hoagland in 1957
(2)
With respect to polymerization of amino acids which of the following statements is wrong?
[A]
The polymerization machinery consists of fifty proteins and two RNA molecules
[B]
Overall molecular mass 2.5 megadalton
[C]
Occurs at a slow pace of only 2 – 20 amino acids per second
[D]
In eukaryotes the process occurs in the cytoplasm
Answer: The polymerization machinery consists of fifty proteins and two RNA molecules
(3)
Ribosome begins its translation at the 3’ end of the mRNA in prokaryotes.
(4)
Check which one of the following mechanisms is wrongly paired with its location of occurrence?
[A]
Transcription – nucleus
[B]
Post transcriptional mechanism – ER
[C]
Translation – cytoplasm
[D]
Post translational mechanism – ER
Answer: Post transcriptional mechanism – ER
(5)
With respect to the subunits of ribosome which of the following is wrongly paired?
[A]
Ribosome = rRNA + protein
[B]
Large subunit = decoding center
[C]
Small subunit = decoding center
[D]
Subunit sedimentation unit = Svedberg
Answer: Large subunit = decoding center
(6)
An mRNA bearing multiple ribosomes is known as______________
[A]
Small subunit-mRNA-initiator tRNA complex
[B]
mRNA ribosome complex
[C]
Polyamine-ribosome complex
[D]
Polysome
(7)
What is the actual substrate for each round of amino acid addition?
[A]
Ribosome
[B]
Amino acid
[C]
mRNA
[D]
tRNA
(8)
The reaction to form a new peptide bond is known as the peptidyl transferase reaction.
(9)
Where does ribosome gets the energy for the formation of peptide bond?
[A]
Breaking of the keto bond
[B]
Breaking of acyl bond
[C]
Simultaneous hydrolysis of ATP
[D]
Energy released during peptidyl transferase reaction
Answer: Breaking of acyl bond
(10)
With respect to the mRNA – ribosome complex for translation mechanism which of the following pair is wrong?
[A]
Small subunit – decoding center
[B]
A site – aminoacylated tRNA binding site
[C]
P site – peptidyl tRNA binding site
[D]
E site – polypeptide exit site
Answer: E site – polypeptide exit site
(11)
Only a single stranded RNA can pass through the ribosome for decoding.
(12)
How many channels are present in the ribosome?
(13)
Which of the following is a character of ORF?
[A]
Contiguous
[B]
3 – nucleotide codons
[C]
Intron
[D]
Non – overlapping
(14)
With respect to the open reading frame (ORF) which of the following is wrong?
[A]
Starts at 5’ end
[B]
‘AUG’ is the only start codon for both prokaryotes and eukaryotes
[C]
The start codon defines the reading frame for all the subsequent codons
[D]
The stop codon is distinct from the ends of the mRNA
Answer: ‘AUG’ is the only start codon for both prokaryotes and eukaryotes
(15)
With respect to polycistronic mRNAs which of the following is wrong?
[A]
Multiple ORFs
[B]
Found in eukaryotes
[C]
Encodes proteins with related functions
[D]
Multiple polypeptide chain
Answer: Found in eukaryotes
(16)
What was the name of the ribosome binding site?
[A]
ORF
[B]
RBS
[C]
A site
[D]
Shine – Dalgarno sequence
(17)
Which part of the ribosome identifies the Shine – Dalgarno sequence?
[A]
Protein
[B]
16S rRNA
[C]
23S rRNA
[D]
5S rRNA
(18)
Eukaryotic mRNAs recruit ribosomes using the Shine – Dalgarno sequence.
(19)
Eukaryotic mRNA is read in the 3’ to 5’ direction.
(20)
Which one of the following is known as the Kozak sequence?
[A]
5’…..CNNAUCG…..3’
[B]
5’…..GNNAUGG…..3’
[C]
5’…..TNNAUGG…..3’
[D]
5’…..GNNAUGC…..3’
Answer: 5’…..GNNAUGG…..3’
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