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Free download in PDF Short Questions with Answers on Molecular Basis of Inheritance for competitive exams. These short objective type questions with answers are very important for Board exams as well as competitive exams like NEET, AIIMS, JIPMER etc. These short solved questions or quizzes are provided by Gkseries./p>
(1)
What marks the difference between the solenoid and the zig-zag models of 30 nm fibres?
[A]
Linker histone molecule
[B]
Linker DNA
[C]
Nucleosome structure
[D]
10 nm fibre
(2)
The histone tails stabilize the 30 nm fibre by interacting with adjacent nucleosomes.
(3)
Which of the following is not a characteristic of the nuclear scaffold?
[A]
Associated with loops of 40 – 90 kb
[B]
Topoisomerase I
[C]
SMC protein
[D]
Proteinacious in nature
(4)
Which histone molecule produces novel binding sites for protein components of the kinetochore?
[A]
CENP – A
[B]
H2A
[C]
H3
[D]
H4
(5)
With respect to remodeling complex of nucleosome, which of the following is not true?
[A]
Does not require ATP
[B]
Favors sliding of histone
[C]
Favors transfer of histone
[D]
Favors remodeling of histone
Answer: Does not require ATP
(6)
The positioning of nucleosome is beneficial.
(7)
Which of the following facilitates nucleosome positioning?
[A]
Nucleosome remodeling complex
[B]
Topoisomerase II
[C]
SMC protein
[D]
DNA – binding protein
Answer: DNA – binding protein
(8)
Which of the following regions promote histone – DNA association?
[A]
A, T
[B]
A, G
[C]
G, C
[D]
C, T
(9)
With respect to end terminal modification of the histone tail which of the following options is true?
[A]
Lysine – phosphate modification
[B]
Serine – methylation
[C]
Acetylation – transcriptionally active
[D]
Modifications – involvement in gene expression
Answer: Modifications – involvement in gene expression
(10)
Which of the following is a function of a modified histone tail?
[A]
Association with adjacent nucleosome
[B]
Interaction with DNA backbone
[C]
Interaction with chromodomains
[D]
Formation of 40-fold DNA structure
Answer: Interaction with chromodomains
(11)
Bromodomains of proteins are associated with phosphorylated histone tails.
(12)
Which of the following enzymes of transcription commonly contains a bromodomain?
[A]
TFIID
[B]
CDK
[C]
Pre – RC
[D]
DNA polymerase
(13)
Which of the following enzymes is not correctly paired with its function?
[A]
Acetyl transferase – adds acetyl group to lysine
[B]
Methyl transferase – adds methyl group to serine
[C]
Topoisomerase – associated with nuclear scaffold
[D]
Deacetylases – removes acetyl groups from serine
Answer: Methyl transferase – adds methyl group to serine
(14)
Which of the following is not promoted by histone tail modification?
[A]
Formation of repressive structures
[B]
Gene expression
[C]
Nucleosome remodeling
[D]
Nucleosome sliding
Answer: Nucleosome sliding
(15)
Which of the following is not a part of a gene?
[A]
Ori
[B]
Promoter
[C]
Operon
[D]
Terminator
(16)
What is the correct order for increasing gene density?
[A]
Bacteria, Virus, Fruit fly, Human
[B]
Fruit fly, Bacteria, Virus, Human
[C]
Human, Fruit fly, Bacteria, Virus
[D]
Virus, Bacteria, Fruit fly, Human
Answer: Human, Fruit fly, Bacteria, Virus
(17)
Which of these factors contribute to a decrease in gene density?
[A]
Operon
[B]
Intergenic sequence
[C]
Exon sequence
[D]
All of these
Answer: Intergenic sequence
(18)
What do you think is the requirement of Intergenic DNA in higher organisms?
[A]
Just genetic load
[B]
To avoid viable mutations
[C]
Helps in regulation of transcription
[D]
Helps in genome organization
Answer: To avoid viable mutations
(19)
Which of the following is not a character of unique Intergenic DNA?
[A]
Mutant genes
[B]
Pseudogenes
[C]
Palindromes
[D]
Nonfunctional gene fragments
(20)
Which of the following is responsible for the formation of Pseudogenes?
[A]
Polymerase
[B]
Reverse transcriptase
[C]
Klenow fragment
[D]
Wrong primer
Answer: Reverse transcriptase
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